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More than 100 researchers from around the world collaborated in the biggest ever genomic mapping of schizophrenia, for which scientists had previously uncovered only about a couple of dozen risk related genes.

to the point that "we can actually turn the lights on and see what's going on.".

Schizophrenia is a debilitating mental disorder that makes it hard to tell the difference between what is real and not real, and affects about one out of every 100 people. each year. Scientists have long known that genes play a part, and this work further confirms that. Michael O'Donovan, deputy director of the MRC Centre for Neuropsychiatric Genetics and Genomics at Cardiff University School of Medicine in Wales.

Scientists who didn't work on the study were excited by the possibilities it opens up.

The study included the genetic codes of more than 150,000 people nearly 37,000 of them diagnosed with the disease. Researchers found 108 genetic markers for risk of getting the disease, 83 of them not previously reported. And scientists say there are still likely more to be found. "Results like this give you things to work on. It takes it out of the zone Converse Chuck Taylor All Star Ii Reflective Wash High Top

But O'Donovan and McCarroll said the work is way too preliminary to even hint at that. Even the people with elevated risk of schizophrenia according to the test were far more likely to be free of the disorder than to have it.

Dr. Thomas Insel, director of the National Institute of Mental Health, which funded the work, said the study Womens White Leather Converse Shoes provides useful hints about the biology of the disease, especially the link to the immune system.

"It's a map or maze. It's telling you were to start, it's not telling you where to end," O'Donovan said.

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´╗┐Genetic mapping triggers new hope on schizophrenia

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"This makes me more optimistic than I was yesterday," said American Psychiatric Association president Dr. Thomas Summergrad, psychiatrist in chief at Tufts Medical Center.

But he said the study of schizophrenia genetics is now Converse All Star Shoes Black

of guesses about which genes are relevant."

WASHINGTON (AP) Scientists have linked more than 100 spots in our DNA to the risk of developing schizophrenia, casting light on the mystery of what makes the disease tick.

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O'Donovan figures most people have at least 20 to 30 genes that nudge them toward developing schizophrenia, probably many more, but don't have the disorder itself. That's because it may still take an environmental or emotional trigger to bring on the illness.

Insel was especially excited about one study finding, that people with the most genetic markers were 15 times more likely to have schizophrenia than those with the fewest markers. He said he hoped that scientists can eventually develop a genetic test to identify young people at high risk for the disease, so they can be offered early treatment.

related to schizophrenia risk because each gene generally has only a very weak effect.

With the new work, "now it's very clear that there's something going in the immune system" with schizophrenia, said Eric Lander, founding director of the Broad Institute, which was heavily involved in the research.

"This really is a big step forward," Insel said. "It's not an answer; it's a step forward toward an answer."

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The results were released Monday by the journal Nature. It takes large studies to ferret out genes Converse All Star Shoes Blue

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Such work could eventually point to new treatments, although they are many years away. Already, the new results provide the first hard genetic evidence to bolster a theory connecting the immune system to the disease.

Scientists already knew that families with autoimmune disorders tend to have higher rates of schizophrenia, and there's been a link between certain viral infections in the second trimester of pregnancy and higher rates of schizophrenia in offspring, Insel said.

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