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"The ProSavin study was a positive and important first step for a potential gene therapy for Parkinson disease," said Dr. Michael Okun, national medical director at the National Parkinson Foundation. "The results of this preliminary study revealed a promising safety profile, and it will be interesting to observe longer term benefits and how ProSavin will compare to other therapies such as deep brain stimulation."

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Mitrophanous thinks this new treatment will eventually outperform deep brain stimulation or levodopa.

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Over time, patients need larger doses of levodopa. Its benefit starts to wear off five to 10 years after starting the drug, he said.

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The therapy, called ProSavin, works by reprogramming brain cells to produce dopamine, the chemical essential for controlling movement, the researchers said. Lack of dopamine causes the tremors, limb stiffness and loss of balance that patients with the neurodegenerative disease suffer.

´╗┐Gene therapy may hold promise for advanced Parkinson's disease

Experts reacted positively but cautiously to the findings, which were published online Jan. 10 in The Lancet. While the treatment seems safe, its potential as a replacement for current therapy still must be proved, they noted.

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Scientists 'rewrite' bad memories in miceScientists 'rewrite' bad memories in mice

Young adults who had depression have 'hyper connected' brain networksYoung adults who had depression have 'hyper connected' brain networks

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Young adults who struggled with depression in adolescence appear to have "hyper connected" networks in their brain, researchers are reporting.

Hoping to improve on their results, the researchers have since re engineered the therapy. "We have a new version which makes more dopamine in patients, and this new version is undergoing safety studies before we initiate trails in patients," he said.

peaks and valleys often produced by the drug levodopa, the current standard treatment, Mitrophanous said.

Young adults who struggled with depression in adolescence appear to have "hyper connected" networks in their brain, researchers are reporting.

Someone who has been mugged in a dark alley will likely never want to return there, having associated that location with a fear of being attacked.

seem to have recovered from a concussion may actually show a subtle worsening in a particular mental ability after they return to exercise, a small study suggests.

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The treatment uses a harmless virus to deliver three dopamine making genes directly to the area of the brain that controls movement, he explained. These genes are able to convert non dopamine producing nerve cells into dopamine producing cells.

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Although the study results are promising, the researchers suggest they should be "interpreted with caution" because the perceived benefits fall into the range of "placebo effect" seen with other clinical trials.

Patients can then try deep brain stimulation, which involves putting wires into the brain that are attached to a battery pack, Mitrophanous said.

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By Steven ReinbergTHURSDAY, Jan. 9, 2014 (HealthDay News) A new, preliminary treatment involving triple gene therapy appears safe and effective in helping to control motor function in Parkinson disease patients, according to new research.

"We demonstrated that we are able to safely administer genes into the brain of patients and make dopamine, the missing agent in Parkinson patients," said researcher Kyriacos Mitrophanous, head of research at Oxford BioMedica in England, the company that developed the therapy and funded the study.

Someone who has been mugged in a dark alley will likely never want to return there, having associated that location with a fear of being attacked.

California trees harbor fungus deadly to people with HIVCalifornia trees harbor fungus deadly to people with HIV

A potentially deadly fungus that has been sickening HIV/AIDS patients in Southern California for decades grows on trees, a new study finds.

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